Brain Metastasis

Brain metastases arise within systemic cancers but evolve under distinct selective pressures imposed by the brain microenvironment, local therapy, and prior systemic treatment. Their biology cannot be fully inferred from the primary tumor alone.

Longitudinal schematic from a primary tumor through brain metastasis and later recurrence, integrating genomics, ecDNA, single-cell and spatial profiling, imaging, and treatment history.
Longitudinal integration of primary tumors, brain metastases, clinical timelines, and multimodal profiling maps metastatic evolution across space and time. View full-size illustration

Longitudinal and matched cohorts

We are developing longitudinal and matched primary–brain metastasis cohorts to study clonal evolution, extrachromosomal DNA, cellular states, immune context, and treatment resistance across disease sites and time. Our work integrates archival and prospectively acquired specimens with genomics, single-cell and spatial assays, imaging, and structured clinical annotation.

Atlases and multimodal models

A parallel computational effort is developing interoperable atlases and multimodal models that can support cross-institutional studies and, ultimately, clinical decision support.

Consortium participation

BRIDGE network diagram linking an international consortium, longitudinal patient journey, TRACE sample matching, BMCA atlas construction, multimodal profiling, and governed data resources.
BRIDGE connects international sites, longitudinal patient data, TRACE sample matching, BMCA atlas construction, multimodal profiling, and governed data resources. View full-size illustration

Contact us about brain-metastasis collaboration