Publications

The Diaz Lab develops and applies single-cell, spatial, genomic, and computational approaches to study brain-tumor evolution, therapeutic resistance, and tumor immunity. Selected publications are shown below.

The phenotypes of proliferating glioblastoma cells reside on a single axis of variation

Wang L, Babikir H, Muller S, Yagnik G, Shamardani K, Catalan F, Kohanbash G, Alvarado B, Di Lullo E, Kriegstein A, Shah S, Wadhwa H, Chang SM, Philips JJ, Aghi MK, Diaz AA

Cancer Discov. 2019 Sep 25; pii: CD-19-0329. doi: 10.1158/2159-8290.CD-19-0329. [Epub ahead of print].

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Single-cell profiling of human gliomas reveals macrophage ontogeny as a basis for regional differences in macrophage activation in the tumor microenvironment.

Müller S, Kohanbash G, Liu SJ, Alvarado B, Carrera D, Bhaduri A, Watchmaker PB, Yagnik G, Di Lullo E, Malatesta M, Amankulor NM, Kriegstein AR, Lim DA, Aghi M, Okada H, Diaz A

Genome Biol. 2017 Dec 20; 18 (1): 234. doi: 10.1186/s13059-017-1362-4.

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Single-cell sequencing maps gene expression to mutational phylogenies in PDGF and EGF driven gliomas

Müller S, Liu SJ, Di Lullo E, Malatesta M, Pollen A, Nowakowski TJ, Kohanbash G, Aghi M, Kriegstein A, Lim DA, Diaz A

Mol Syst Biol. 2016 Nov 25; 12 (11): 889. doi: 10.15252/msb.20166969.

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