Beatriz Alvarado
Coming from a background in single-cell technologies research, I was very interested in harnessing the power of single-cell transcriptomics to investigate changes during brain development and disease progression. While working in the Diaz lab I used single cell RNA-sequencing to study gene expression changes in glioblastoma and low grade gliomas.
2017 - Present: Developmental and Stem Cell Biology Ph.D. student, UCSF
2015 - 2017: Associate Specialist, Diaz Lab & Kriegstein Labs
Single-cell profiling of human gliomas reveals macrophage ontogeny as a basis for regional differences in macrophage activation in the tumor microenvironment.
Müller S, Kohanbash G, Liu SJ, Alvarado B, Carrera D, Bhaduri A, Watchmaker PB, Yagnik G, Di Lullo E, Malatesta M, Amankulor NM, Kriegstein AR, Lim DA, Aghi M, Okada H, Diaz A.
Genome Biol. 2017 Dec 20;18(1):234. doi: 10.1186/s13059-017-1362-4.
Spatiotemporal gene expression trajectories reveal developmental hierarchies of the human cortex.
Nowakowski TJ, Bhaduri A, Pollen AA, Alvarado B, Mostajo-Radji MA, Di Lullo E, Haeussler M, Sandoval-Espinosa C, Liu SJ, Velmeshev D, Ounadjela JR, Shuga J, Wang X, Lim DA, West JA, Leyrat AA, Kent WJ, Kriegstein AR.
Science. 2017 Dec 8;358(6368):1318-1323. doi: 10.1126/science.aap8809.
A single-cell atlas of human glioblastoma reveals a single axis of phenotype in tumor-propagating cells
Müller S, Di Lullo E, Bhaduri A, Alvarado B, Yagnik G, Kohanbash G, Aghi M, Diaz A.
Science. 2017 Dec 8;358(6368):1318-1323. doi: 10.1126/science.aap8809.