Diaz Lab MSB cover art

Publications

The Diaz Lab develops and applies single-cell, spatial, genomic, and computational approaches to study brain-tumor evolution, therapeutic resistance, and tumor immunity. Selected publications are shown below.

 

MAPK-driven glioma progression and reprogramming of the tumor-associated immune response

Hashemi E, Akshaya RL, Wang L, Bergland S, Piyadasa H, Ranek JS, Voong V, Kshirsagar A, Shai A, Oberlton B, Kumar A, Berger MS, Chang EF, Oldham MC, Prins RM, Bendall SC, Angelo M, Hervey-Jumper SL, Okada H, Diaz A, Phillips JJ.

Neuro Oncol. 2026 Jun 30; noag147. Epub ahead of print.
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Single-nucleus profiling of postmortem diffuse midline gliomas identifies mitochondrial biogenesis as a resistance mechanism to imipridone therapy

Okada M, Subramaniam B, Geng B, Jung J, Yu B, Lin F, Fu Y, Wang Y, Yu W, Laternser S, Gupta N, Müller S, Wang L, Diaz A, Nazarian J.

Neuro Oncol. 2026 Sep 1; 28 (9): 2248-2262. doi: 10.1093/neuonc/noag119.
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AAV immuno-gene therapy platform delivering vectorized cytokines defines a new modality for high-grade glioma treatment

Kuwahara A, Fenton EM, Lovejoy C, Lee T, Wang L, Fogarty M, Jung J, Guo SM, Maynard LH, May AP, Rossenberg-Hasson Y, Clarke JL, Diaz AA, Phillips JJ, Kelly L, Clément N, Paulk NK.

Mol Ther Oncol. 2026 Mar 20; 34 (2): 201183. doi: 10.1016/j.omton.2026.201183.
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Measles Oncolytic Virus as an Immunotherapy for Recurrent/Refractory Pediatric Medulloblastoma and Atypical Teratoid/Rhabdoid Tumor: Results from PNOC005

Yu B, Kline C, Hoare O, Jung J, Knowles T, Ranavaya A, Minturn J, Banerjee A, Leary S, Crotty E, Abdelbaki M, Whipple N, Goldman S, Margol A, Bhatia A, Dababo N, George E, Nabavizadeh A, Pampaloni MH, Inagaki A, Collins S, Chuntova P, Barcova M, Patel TS, Phillips J, Prados M, Molinaro A, Gupta N, Raffel C, Cole K, Kasahara N, Diaz AA, Mueller S.

Clin Cancer Res. 2025 Aug 14; 31 (16): 3463-3475. doi: 10.1158/1078-0432.CCR-24-3721.
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Tumour-wide RNA splicing aberrations generate actionable public neoantigens

Chan GKL, Liu J, Wu SH, Ramos E, Yamamichi A, Watchmaker PB, Ogino H, Saijo A, Du A, Grishanina NR, Woo J, Diaz A, Hervey-Jumper SL, Chang SM, Phillips JJ, Wiita AP, Klebanoff CA, Costello JF, Okada H.

Nature. 2025 Mar 1; 639 (8054): 463-473. doi: 10.1038/s41586-024-08552-0. Epub 2025 Feb 19.
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The T cell receptor landscape of childhood brain tumors

Raphael I, Xiong Z, Sneiderman CT, Raphael RA, Mash M, Schwegman L, Jackson SA, O'Brien C, Anderson KJ, Sever RE, Hendrikse LD, Vincze SR, Diaz A, Felker J, Nazarian J, Nechemia-Arbely Y, Hu B, Kammula US, Agnihotri S, Rich JN, Broniscer A, Drappatz J, Abel TJ, Uttam S, Hwang EI, Pearce TM, Taylor MD, Nisnboym M, Forsthuber TG, Pollack IF, Chikina M, Rajasundaram D, Kohanbash G.

Sci Transl Med. 2025 Mar 19; 17 (790): eadp0675. doi: 10.1126/scitranslmed.adp0675.
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Longitudinal multimodal profiling of IDH-wildtype glioblastoma reveals the molecular evolution and cellular phenotypes underlying prognostically different treatment responses

Lucas CG, Al-Adli NN, Young JS, Gupta R, Morshed RA, Wu J, Ravindranathan A, Shai A, Oberheim Bush NA, Taylor JW, de Groot J, Villanueva-Meyer JE, Pekmezci M, Perry A, Bollen AW, Theodosopoulos PV, Aghi MK, Chang EF, Hervey-Jumper SL, Raleigh DR, Molinaro AM, Costello JF, Diaz AA, Clarke JL, Butowski NA, Phillips JJ, Chang SM, Berger MS, Solomon DA

Neuro Oncol. 2025 Jan 12; 27 (1): 89-105. doi: 10.1093/neuonc/noae214.
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Glioblastoma induces the recruitment and differentiation of dendritic-like "hybrid" neutrophils from skull bone marrow

Lad M, Beniwal AS, Jain S, Shukla P, Kalistratova V, Jung J, Shah SS, Yagnik G, Saha A, Sati A, Babikir H, Nguyen AT, Gill S, Rios J, Young JS, Lui A, Salha D, Diaz A, Aghi MK.

Cancer Cell. 2024 Sep 9; 42 (9): 1549-1569. doi: 10.1016/j.ccell.2024.08.008.
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VC-resist glioblastoma cell state: vessel co-option as a key driver of chemoradiation resistance

Pichol-Thievend C, Anezo O, Pettiwala AM, Bourmeau G, Montagne R, Lyne AM, Guichet PO, Deshors P, Ballestín A, Blanchard B, Reveilles J, Ravi VM, Joseph K, Heiland DH, Julien B, Leboucher S, Besse L, Legoix P, Dingli F, Liva S, Loew D, Giani E, Ribecco V, Furumaya C, Marcos-Kovandzic L, Masliantsev K, Daubon T, Wang L, Diaz AA, Schnell O, Beck J, Servant N, Karayan-Tapon L, Cavalli FMG, Seano G.

Nat Commun. 2024 Apr 29; 15 (1): 3602. doi: 10.1038/s41467-024-47985-z.
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Challenges in the discovery of tumor-specific alternative splicing-derived cell-surface antigens in glioma

Maldonado GC, Yamamichi A, Watchmaker PB, Naik A, Shai A, Phillips JJ, Chang SM, Wiita AP, Wells JA, Costello JF, Diaz AA, Okada H.

Sci Rep. 2024 Mar 16; 14 (1): 6362. doi: 10.1038/s41598-024-56684-0.
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Single-cell RNA sequencing and spatial transcriptomics reveal cancer-associated fibroblasts in glioblastoma with protumoral effects

Chang AC, Choudhary N, Nguyen AT, Sudhir S, Chalif EJ, Chen JS, Chandra A, Haddad AF, Wadhwa H, Shah SS, Choi S, Hayes JL, Wang L, Yagnik G, Costello JF, Diaz A, Heiland DH, Aghi MK.

J Clin Invest. 2023 Mar 1; 133 (5): e147087. doi: 10.1172/JCI147087.
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A single-cell atlas of glioblastoma evolution under therapy reveals cell-intrinsic and cell-extrinsic therapeutic targets

Wang L, Jung J, Babikir H, Shamardani K, Jain S, Feng X, Gupta N, Rosi S, Chang S, Raleigh D, Solomon D, Phillips JJ, Diaz AA.

Nat Cancer. 2022 Dec 20; 3 (12): 1534-1552. doi: 10.1038/s43018-022-00475-x.
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ATRX regulates glial identity and the tumor microenvironment in IDH-mutant glioma

Babikir H, Wang L, Shamardani K, Catalan F, Sudhir S, Aghi MK, Raleigh DR, Phillips JJ, Diaz AA.

Genome Biol. 2021 Nov 11; 22 (1): 311. doi: 0.1186/s13059-021-02535-4.
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The evolution of alternative splicing in glioblastoma under therapy

Wang L, Shamardani K, Babikir H, Catalan F, Nejo T, Chang S, Phillips JJ, Okada H, Diaz AA.

Genome Biol. 2021 Jan 26; 22 (1): 48. doi: 10.1186/s13059-021-02259-5.
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The phenotypes of proliferating glioblastoma cells reside on a single axis of variation

Wang L, Babikir H, Muller S, Yagnik G, Shamardani K, Catalan F, Kohanbash G, Alvarado B, Di Lullo E, Kriegstein A, Shah S, Wadhwa H, Chang SM, Philips JJ, Aghi MK, Diaz AA

Cancer Discov. 2019 Sep 25; pii: CD-19-0329. doi: 10.1158/2159-8290.CD-19-0329. [Epub ahead of print].
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